Rewriting cellular identity to reverse aging, repair tissues, and redefine what is biologically possible.
Cell reprogramming is the process of changing a cell’s identity by altering its gene expression patterns — without changing its DNA. In simple terms, it means teaching a cell to behave like a younger or different type of cell.
A skin cell can be reprogrammed into a stem-like state, or partially rejuvenated to restore youthful function while keeping its original role.
In 2006, Shinya Yamanaka discovered that introducing four transcription factors (OSKM) could revert adult cells into induced pluripotent stem cells (iPSCs).
This discovery reshaped biology and earned a Nobel Prize.
Full reprogramming resets identity completely — but partial reprogramming resets aging markers while preserving cell function.
This approach is considered one of the most promising anti-aging strategies.
Aging can be measured using epigenetic clocks based on DNA methylation. Cell reprogramming has been shown to reverse these clocks in animal models.
Cell reprogramming is expected to integrate with: